There are many different games in HORSE and that makes it hard to give tips away in regards to the game of poker horse itself, but for the hi/lo part it is always advised to only play hands till the end if you feel you can win both or win one and split the other. Furthermore it is important to think about the limit variant of the games and not the NO Limit variety you might be used to play.  This means that a lot of players will stay in pots longer with draws and worse hands then you. Also when having excellent hands in for instance Texas HoldEm with AA it is hard to win a pot pre flop or on the flop because of the fact it is limit poker.  These H.O.R.S.E poker tips should help make you the best player at the table.
Know what you are playing. This is a rule you should never forget to check. If you play HORSE online the blinds can go up almost unnoticed and games can be switched while you poor a cup of coffee or say hello to the other half. On the top part of your screen all the poker room will tell you what game you are playing.